Avascular Necrosis (AVN) refers to a medical condition where the bone tissue starts to die because of a lack of blood supply. It typically happens in joints like the hip, shoulder, or knee. With no blood supply, the bone eventually weakens, causing pain, swelling, and stiffness while moving. The affected joint might collapse later on unless it is detected early. AVN could be a consequence of injury, long-term steroid therapy, excessive alcohol intake, or health conditions like sickle cell disease and lupus.

Exosome therapy is a new and cutting-edge treatment that could potentially be used to cure AVN. Exosomes are microscopic healing messengers secreted by cells naturally. They carry proteins, growth factors, and genetic materials that help to heal injured tissue. In AVN, exosome therapy does this by sending messages to the damaged bone area. This helps to slow down or even reverse AVN’s destruction.

Reasons To Choose Exosome Therapy for Avascular Necrosis

Exosome therapy helps to treat individuals who are suffering from avascular necrosis. It is a new technique that enhances the body’s ability to heal itself. For individuals suffering from bone damage and decreased blood supply to the joints, this therapy can be quite beneficial. Here are the benefits of exosome therapy:

• Reduces Joint Pain Naturally: Most individuals who have this condition have ongoing pain in their hips, knees, or shoulders. Exosome therapy can prevent pain without heavy meds or surgery. It quiets inflammation and rubs the irritated area.

• Promotes Healthy Bone Regrowth: The therapy is able to get the body to repair damaged tissues. With time, it is able to restore bone strength by stimulating the healing process deep within the joint.

• Enhances Mobility and Movement: Following therapy, individuals experience improvements in the movement of the affected area. They are able to walk or bend with more difficulty to make it easier to resume daily activities.

• Delay Disease Progression: This treatment, if applied early, can delay the degeneration caused by inadequate blood supply in the bones. It achieves this by enhancing the local environment within the joint such that it becomes a better support for bones.

• Avoids Complicated Surgeries: Most individuals prefer not to undergo joint replacement or invasive procedures. This treatment may provide a less invasive alternative that does not carry risks of long recoveries or hospitalization.

• Rapid and Low-Risk Recovery: The procedure is generally straightforward and is not performed with general anesthesia. Most individuals are allowed to go home the same day. There are also fewer risks of infection or severe side effects than with surgery.

Steps Used in Exosome Therapy

Exosome therapy works by repairing damaged tissues and helping new healthy cells grow in the affected bone. The process happens in several steps, which are explained below in simple terms. Here is how exosome therapy works:

Step 1: Collection of Exosomes

The first step is to harvest exosomes from safe and reliable sources, like stem cells. The exosomes contain beneficial signals that facilitate healing. Once they are harvested, they are purified and prepared for use in treatment.

Step 2: Targeted Delivery to the Affected Bone

The exosomes are then injected slowly into the region of bone where the blood supply has been cut off. This allows them to be delivered to the affected tissue in a direct manner and commence their functioning in the current location.

Step 3: Stimulation of Healing Signals 

In the targeted area, exosomes release unique proteins and messages. These signals instruct the body to initiate repair work and make adjacent cells wake up and initiate repairing the injured bone tissue.

Step 4: Stimulation of New Blood Vessels

Exosomes promote the formation of small new blood vessels in the dead bone region. The new blood vessels supply oxygen and nutrients, which are necessary for healthy bone repair and to prevent further damage.

Step 5: Reducing Inflammation and Cell Death

The signals for healing also quiet the area by inhibiting inflammation and preventing further bone cells from becoming damaged. This process is crucial for pain management and halting the affliction’s progression.

Step 6: Bone and Healthy Tissue Regeneration

Lastly, the treatment causes new bone and supportive tissues to form in place of the destroyed ones. With time, this reconstructs the bone structure and enhances its strength and function.

How Can You Find Out If Exosome Therapy is Working?

Exosome therapy has initial and continued results that make the patient feel better with time. It affects the body at a very deep level, and its impact tends to be evident and tangible in everyday ways. Some working signs indicating that the therapy is effective are listed below:

• Less Joint Pain: One of the earliest signs that most people observe is a decrease in joint pain. The painful movements become smoother. The pain decreases both during movement and at rest. This improvement usually occurs gradually but consistently.

• Improved Movement of Joints: Individuals tend to notice that they can move the involved joint more smoothly. Bending, walking, or turning is smoother. There is less stiffness, particularly upon waking or after sitting for an extended period.

• Increased Daily Comfort: The daily activity tasks, such as walking up stairs or rising from a chair, are less strenuous. This is a definite indication that the therapy is taking effect from the inside and causing the body to heal damaged tissue.

• Decreased Swelling or Inflammation: Others might see less swelling in the joint area. The region will be less warm or painful, too. All of these signs tend to indicate that the body’s immune response is settling down in the region.
• More Strength or Balance: As the joint stabilizes, patients can expect stronger limbs. Standing, walking, or bearing weight becomes more balanced. This reduces the likelihood of falling or re-injuring the area.
• Improved Results on Scans: Whereas most symptoms are noticed in everyday living, scans in the doctor’s office (such as an MRI) can also improve. Bone tissue can appear healthier, and damage can cease or decrease.